| Substance |
Info | Dose |
Warn | Link |
PubMed |
Latest article |
| Red Yeast Rice | 📋 | ✍ | ⛔ | | 38480501 | Red Yeast Rice and Statin Therapy in Patients with Hypercholesterolemia and the Comorbidities: A Retrospective Cohort Study on Lipid-Lowering Effects and Cardiovascular Outcomes |
| Berberine | 📋 | ✍ | ⛔ | | 38424708 | Berberine attenuates inflammation and oxidative stress and modulates lymphocyte E-NTPDase in acute hyperlipidemia |
| Curcumin | 📋 | ✍ | ⛔ | | 38290567 | Curcumin nicotinate increases LDL cholesterol uptake in hepatocytes through IDOL/LDL-R pathway regulation |
| Coconut Oil | 📋 | | ⛔ | | 37708389 | Effect of Virgin Coconut Oil (VCO) on Cardiometabolic Parameters in Patients with Dyslipidemia: A Randomized, Add-on Placebo-Controlled Clinical Trial |
| Omega-3 Fatty Acids | 📋 | ✍ | ⛔ | | 38338520 | Different Sources of Omega-3 Fatty Acid Supplementation vs. Blood Lipid Profiles-A Study on a Rat Model |
| CoQ10 | 📋 | ✍ | ⛔ | | 37375586 | Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts Lowers LDL Cholesterol in Patients with Mild Dyslipidemia: A Multicenter, Randomized Controlled Trial |
| Bergamot | 📋 | ✍ | ⛔ | | 37732063 | Metabolic and vascular effect of a new standardized bergamot phytocomplex: a three-arm, placebocontrolled, double-blind clinical trial |
| Vitamin D3 | 📋 | ✍ | ⛔ | | 38536498 | Effect of vitamin D3 supplementation on blood parameters and liver gene expression in female rats |
| Cocoa | 📋 | ✍ | ⛔ | | 37242181 | Regular Consumption of Cocoa and Red Berries as a Strategy to Improve Cardiovascular Biomarkers via Modulation of Microbiota Metabolism in Healthy Aging Adults |
| Pantethine | 📋 | ✍ | ⛔ | | 37194410 | Pantethine ameliorates recognition impairment in a mouse model of Alzheimer's disease by modulating cholesterol content and intestinal flora species |
| Almond | 📋 | | ⛔ | | 36704786 | Effect of almond consumption on insulin sensitivity and serum lipids among Asian Indian adults with overweight and obesity- A randomized controlled trial |
| Grape Seed extract | 📋 | ✍ | ⛔ | | 38007734 | Effect of Grape Seed Procyanidins Combined with Allicin on Lipid Levels in Hyperlipidemic Rats |
| Fenugreek | 📋 | ✍ | ⛔ | | 35936152 | A Comparative Study on Clinical Evaluation of the Hypolipidemic Effects of Allium sativum, Trigonella foenum-graecum, Commiphora mukul, Picrorhiza kurroa, and Piper nigrum: A Pilot Study |
| Garlic | 📋 | ✍ | ⛔ | | 38008957 | Synergistic effect of Moringa oleifera and Allium sativum on BMI and lipid profile: A randomized controlled trial |
| Oats | 📋 | | ⛔ | | 38477294 | Oat protein modulates cholesterol metabolism and improves cardiac systolic function in high fat, high sucrose fed rats |
| Walnut | 📋 | | ⛔ | | 38089061 | The antihyperlipidemic effect of a combined supplement of standardized dry extracts of amla ( Emblica officinalis), walnut ( Juglans regia), olive ( Olea europaea) and red yeast rice ( Monascus purpureus) powder: Reduction in circulatory low-density lipoprotein-cholesterol (LDL-C) and remnant cholesterol (RC) levels in patients with hypercholesterolemia |
| Nigella Sativa | 📋 | ✍ | ⛔ | | 36909699 | A review on hypo-cholesterolemic activity of Nigella sativa seeds and its extracts |
| Vitamin B3 | 📋 | ✍ | ⛔ | | 33761625 | The efficacy of niacin supplementation in type 2 diabetes patients: Study protocol of a randomized controlled trial |
| Argan Oil | 📋 | ✍ | ⛔ | | 29299990 | Aqueous Extract of Argania spinosa L. Fruits Ameliorates Diabetes in Streptozotocin-Induced Diabetic Rats |
| Astaxanthin | 📋 | ✍ | ⛔ | | 37051124 | Effects of Astaxanthin supplementation on selected metabolic parameters, anthropometric indices, Sirtuin1 and TNF-α levels in patients with coronary artery disease: A randomized, double-blind, placebo-controlled clinical trial |
| Cinnamon | 📋 | ✍ | ⛔ | | 37909519 | Effectiveness of cinnamon in the reduction of lipid levels in people with diabetes: a randomized clinical trial |
| Fish Oil | 📋 | ✍ | ⛔ | | 38317191 | Comparison of fish oil supplements and corn oil effects on serum lipid profile: a systematic review and meta-analysis of randomized controlled trials |
| Olive Oil | 📋 | ✍ | ⛔ | | 37571288 | The Metabolic and Analytical Changes of Healthy Volunteers upon Intake of Portuguese Extra Virgin Olive Oil: A Comparison Study between Pre- and Post-Intervention |
| Sea Buckthorn | 📋 | ✍ | ⛔ | | 38007790 | Protective Effect of Sea Buckthorn (Hipphophae Rhamnoides) Extract on Liver Injury Induced by High-Fat Diet in Mice |
| Anthocyanins | 📋 | ✍ | ⛔ | | 37649528 | Effects of anthocyanin supplementation on blood lipid levels: a systematic review and meta-analysis |
| Reishi Mushrooms | 📋 | ✍ | ⛔ | | 38116485 | Effect of Ganoderma lucidum on serum lipid profiles: A systematic review and meta-analysis on animal studies |
| Lycopene | 📋 | ✍ | ⛔ | | 36422550 | Lycopene Modulates Oxidative Stress and Inflammation in Hypercholesterolemic Rats |
| Spirulina | 📋 | ✍ | ⛔ | | 37263369 | The effect of Spirulina supplementation on lipid profile: GRADE-assessed systematic review and dose-response meta-analysis of data from randomized controlled trials |
| Hawthorn | 📋 | ✍ | ⛔ | | 38482041 | Efficacy of traditional Chinese medicine containing hawthorn for hyperlipidemia: a systematic review and meta-analysis |
| Psyllium | 📋 | ✍ | ⛔ | | 38688104 | Plantago consumption significantly reduces total cholesterol and low-density lipoprotein cholesterol in adults: A systematic review and meta-analysis |
| Resveratrol | 📋 | ✍ | ⛔ | | 37826994 | Resveratrol attenuates efavirenz-induced hepatic steatosis and hypercholesterolemia in mice by inhibiting pregnane X receptor activation and decreasing inflammation |
| Chokeberry | 📋 | ✍ | ⛔ | | 34359511 | Black Chokeberry ( Aronia melanocarpa) Functional Beverages Increase HDL-Cholesterol Levels in Aging Rats |
| EGCG | 📋 | ✍ | ⛔ | | 36444016 | Tea polyphenol and epigallocatechin gallate ameliorate hyperlipidemia via regulating liver metabolism and remodeling gut microbiota |
| Fucoidan | 📋 | ✍ | ⛔ | | 38410655 | Hypolipidemic effect of brown seaweed ( Sargassum crassifolium) extract in vivo (Study of histopathology, mRNA expression, and immunohistochemistry (IHC) with VCAM-1, ICAM-1, and MCP-1 parameters) |
| Goji Berry | 📋 | ✍ | ⛔ | | 38628207 | Anthocyanins from Lycium ruthenicum Murray attenuates high-fat diet-induced hypercholesterolemia in ApoE-/- mice are related to the modulation of gut microbiota and the ratio of conjugated to unconjugated bile acids in fecal bile acid profile |
| Green Tea | 📋 | ✍ | ⛔ | | 38162524 | The effect of green tea ( Camellia sinensis) on lipid profiles and renal function in people with type 2 diabetes and nephropathy: a randomized controlled clinical trial |
| L-Carnitine | 📋 | ✍ | ⛔ | | 37727632 | The effect of L-carnitine supplementation on lipid profile in adults: an umbrella meta-analysis on interventional meta-analyses |
| Metformin | 📋 | ✍ | ⛔ | | 37528147 | Influence of rutin and its combination with metformin on vascular functions in type 1 diabetes |
| Mulberry | 📋 | | ⛔ | | 36467763 | Mulberry ( Morus alba L.) ethanol extract attenuates lipid metabolic disturbance and adipokine imbalance in high-fat fed rats |
| Pomegranate | 📋 | | ⛔ | | 38661445 | Pomegranate supplementation alleviates dyslipidemia and the onset of non-alcoholic fatty liver disease in Wistar rats by shifting microbiota and producing urolithin-like microbial metabolites |
| Vitamin C | 📋 | ✍ | ⛔ | | 36386907 | Vitamin C intake potentially lowers total cholesterol to improve endothelial function in diabetic patients at increased risk of cardiovascular disease: A systematic review of randomized controlled trials |
| Capsaicin | 📋 | ✍ | ⛔ | | 36655087 | Capsaicin combined with dietary fiber prevents high-fat diet associated aberrant lipid metabolism by improving the structure of intestinal flora |
| Flaxseed | 📋 | ✍ | ⛔ | | 38663513 | Impact of Flaxseed Supplementation on Lipid Profile and Liver Enzymes in Patients with Non-Alcoholic Fatty Liver Disease: Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| Ginger | 📋 | ✍ | ⛔ | | 36786398 | Effect of ginger (Zingiber officinale) intake on human serum lipid profile: Systematic review and meta-analysis |
| Ginseng | 📋 | ✍ | ⛔ | | 37188264 | Hypolipidemic effect and molecular mechanism of ginsenosides: a review based on oxidative stress |
| Hesperidin | 📋 | ✍ | ⛔ | | 38577143 | Hesperidin Supplementation Improves Altered PON -1, LDL Oxidation, Inflammatory Response and Hepatic Function in an Experimental Rat Model of Hyperlipidemia |
| Lactobacillus plantarum | 📋 | | ⛔ | | 38015360 | Distinct Microbial Taxa Are Associated with LDL-Cholesterol Reduction after 12 Weeks of Lactobacillus plantarum Intake in Mild Hypercholesterolemia: Results of a Randomized Controlled Study |
| Magnesium | 📋 | ✍ | ⛔ | | 38228168 | Effects of co-supplementation of chromium and magnesium on metabolic profiles, inflammation, and oxidative stress in impaired glucose tolerance |
| Roselle | 📋 | ✍ | ⛔ | | 34927694 | A systematic review and meta-analysis of the effects of Hibiscus sabdariffa on blood pressure and cardiometabolic markers |
| Vitamin B9 | 📋 | ✍ | ⛔ | | 38521293 | Folic acid and plasma lipids: interactions and effect of folate supplementation |
| Ginsenosides | 📋 | ✍ | ⛔ | | 38474620 | Ginsenoside Rb1, Compound K and 20(S)-Protopanaxadiol Attenuate High-Fat Diet-Induced Hyperlipidemia in Rats via Modulation of Gut Microbiota and Bile Acid Metabolism |
| Grape | 📋 | | ⛔ | | 37672802 | Concentrated Grape Powder Consumption Modulates Cholesterol Metabolism and Homeostasis in Healthy Subjects |
| Green Tea Polyphenols | 📋 | ✍ | ⛔ | | 33206794 | Effects of green tea extract combined with brisk walking on lipid profiles and the liver function in overweight and obese men: A randomized, double-blinded, placebo-control trial |
| Indian Gooseberry | 📋 | | ⛔ | | 38089061 | The antihyperlipidemic effect of a combined supplement of standardized dry extracts of amla ( Emblica officinalis), walnut ( Juglans regia), olive ( Olea europaea) and red yeast rice ( Monascus purpureus) powder: Reduction in circulatory low-density lipoprotein-cholesterol (LDL-C) and remnant cholesterol (RC) levels in patients with hypercholesterolemia |
| L-Arginine | 📋 | ✍ | ⛔ | | 29793488 | LDL-cholesterol Lowering Effect of a New Dietary Supplement: An Open Label, Controlled, Randomized, Cross-Over Clinical Trial in Patients With Mild-To-Moderate Hypercholesterolemia |
| Luteolin | 📋 | ✍ | ⛔ | | 37408924 | Luteolin reduces cardiac damage caused by hyperlipidemia in Sprague-Dawley rats |
| Ollive Leaf extract | 📋 | ✍ | ⛔ | | 37375586 | Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts Lowers LDL Cholesterol in Patients with Mild Dyslipidemia: A Multicenter, Randomized Controlled Trial |
| Pomegranate Peel extract | 📋 | ✍ | ⛔ | | 36583178 | An open-label study on the short-term effects of a novel EFSA-compliant nutraceutical combination in mild-to-moderate hypercholesterolemia |
| Quercetin | 📋 | ✍ | ⛔ | | 37446770 | Quercetin and Ferulic Acid Elicit Estrogenic Activities In Vivo and In Silico |
| Silymarin | 📋 | ✍ | ⛔ | | 38089157 | Effect of dietary supplementation with a new nutraceutical formulation on cardiometabolic risk factors: a double-blind, placebo-controlled, randomized clinical study |
| Apigenin | 📋 | ✍ | ⛔ | | 36808364 | Apigenin ameliorates hypercholesterolemic-induced kidney injury via modulating renal KIM-1, Fn1, and Nrf2 signaling pathways |
| Coptis Chinensis | 📋 | | ⛔ | | 38677575 | Mechanism of the components compatibility of Scutellariae Radix and Coptidis Rhizoma on mice with hyperlipidemia by regulating the Cyp4a family |
| Cranberry | 📋 | ✍ | ⛔ | | 38542695 | The Effects of Cranberry Consumption on Glycemic and Lipid Profiles in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| Ellagic Acid | 📋 | ✍ | ⛔ | | 36838229 | Supplementation of Weizmannia coagulans BC2000 and Ellagic Acid Inhibits High-Fat-Induced Hypercholesterolemia by Promoting Liver Primary Bile Acid Biosynthesis and Intestinal Cholesterol Excretion in Mice |
| Guggul | 📋 | ✍ | ⛔ | | 37516016 | In-vivo anti-diabetic and anti-hyperlipidemic effects of natural metabolites from resin of Commiphora mukul and their in-silico to in-vitro target fishing |
| Lotus | 📋 | | ⛔ | | 38021260 | Comparison of fresh and browning lotus roots ( Nelumbo nucifera Gaertn.) on modulating cholesterol metabolism via decreasing hepatic cholesterol deposition and increasing fecal bile acid excretion |
| Olive Polyphenols | 📋 | | | | 38132869 | Olive Oil Polyphenols Improve HDL Cholesterol and Promote Maintenance of Lipid Metabolism: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| Orange | 📋 | | ⛔ | | 37548198 | Evaluation of chemical characterization and antihyperlipidemic potential of orange peel powder (Citrus sinensis) in male human subjects |
| Saffron | 📋 | ✍ | ⛔ | | 38207245 | Safety evaluation of saffron extracts in early and established atherosclerotic New Zealand white rabbits |
| Acai Berry | 📋 | ✍ | ⛔ | | 32349893 | Açaí (Euterpe oleracea Mart.) and juçara (Euterpe edulis Mart.) juices improved HDL-c levels and antioxidant defense of healthy adults in a 4-week randomized cross-over study |
| Apple | 📋 | | ⛔ | | 35449537 | Metabolic and Cardiovascular Benefits of Apple and Apple-Derived Products: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| Artichoke | 📋 | ✍ | ⛔ | | 37732047 | Three arms, double-blind, non-inferiority, randomized clinical study testing the lipid-lowering effect of a novel dietary supplement containing red yeast rice and artichoke extracts compared to Armolipid Plus® and placebo |
| Avocado | 📋 | ✍ | ⛔ | | 37525782 | Effect of Avocado Consumption on Risk Factors of Cardiovascular Diseases: A Systematic Review and Meta-Analysis |
| Beta-Glucan | 📋 | ✍ | ⛔ | | 36657917 | The separate effects of whole oats and isolated beta-glucan on lipid profile: A systematic review and meta-analysis of randomized controlled trials |
| Chlorogenic Acid | 📋 | ✍ | ⛔ | | 38103317 | Chlorogenic acid regulates the expression of NPC1L1 and HMGCR through PXR and SREBP2 signaling pathways and their interactions with HSP90 to maintain cholesterol homeostasis |
| Chromium | 📋 | ✍ | ⛔ | | 38228168 | Effects of co-supplementation of chromium and magnesium on metabolic profiles, inflammation, and oxidative stress in impaired glucose tolerance |
| Date | 📋 | | ⛔ | | 37333476 | Effect of Ajwa date pits powder ( Phoenix dactylifera L.) on body composition, lipid profile and blood pressure in patients with hyperlipidemia: A randomized clinical trial |
| Food | 📋 | | | | 37349839 | Dietary intervention for children and adolescents with familial hypercholesterolaemia |
| Ginger extract | 📋 | ✍ | ⛔ | | 31379996 | Effect of Hydroalcoholic Ginger Extract on Brain HMG-CoA Reductase and CYP46A1 Levels in Streptozotocin-induced Diabetic Rats |
| Melatonin | 📋 | ✍ | ⛔ | | 35707823 | Melatonin relieves diabetic complications and regenerates pancreatic beta cells by the reduction in NF-kB expression in streptozotocin induced diabetic rats |
| Moringa Oleifera | 📋 | ✍ | ⛔ | | 38008957 | Synergistic effect of Moringa oleifera and Allium sativum on BMI and lipid profile: A randomized controlled trial |
| Pistachio | 📋 | ✍ | ⛔ | | 34933637 | Consumption of pistachio nuts positively affects lipid profiles: A systematic review and meta-analysis of randomized controlled trials |
| Punicalagin | 📋 | ✍ | ⛔ | | 35565844 | Oral Supplement Containing Hydroxytyrosol and Punicalagin Improves Dyslipidemia in an Adult Population without Co-Adjuvant Treatment: A Randomized, Double-Blind, Controlled and Crossover Trial |
| Soy | 📋 | ✍ | ⛔ | | 38342411 | Effect of unfermented soy product consumption on blood lipids in postmenopausal women: A systematic review and meta-analysis of randomized controlled trials |
| Star Fuit | 📋 | | ⛔ | | 36814487 | Averrhoa carambola leaves prevent dyslipidemia and oxidative stress in a rat model of poloxamer-407-induced acute hyperlipidemia |
| Strawberry | 📋 | ✍ | ⛔ | | 37462847 | The Hypoglycemic and Hypolipidemic Effects of Polyphenol-Rich Strawberry Juice on Diabetic Rats |
| Bilberry | 📋 | ✍ | ⛔ | | 36169276 | Phytonutrients of bilberry fruit and saskatoon berry in the prevention and treatment of dyslipidemia |
| Brazil Nut | 📋 | | ⛔ | | 28501922 | SEPP1 polymorphisms modulate serum glucose and lipid response to Brazil nut supplementation |
| Camellia | 📋 | | ⛔ | | 36466393 | Combining effect of camellia oil and squalene on hyperlipidemia-induced reproductive damage in male rats |
| Coffee | 📋 | ✍ | ⛔ | | 37049443 | Twelve-Week Safety and Potential Lipid Control Efficacy of Coffee Cherry Pulp Juice Concentrate in Healthy Volunteers |
| Egg | 📋 | | ⛔ | | 38500805 | Eggs and a Fiber-Rich Diet Are Beneficially Associated with Lipid Levels in Framingham Offspring Study Adults |
| Fiber | 📋 | ✍ | ⛔ | | 38500805 | Eggs and a Fiber-Rich Diet Are Beneficially Associated with Lipid Levels in Framingham Offspring Study Adults |
| Genistein | 📋 | ✍ | ⛔ | | 38115108 | Identifying the natural products in the treatment of atherosclerosis by increasing HDL-C level based on bioinformatics analysis, molecular docking, and in vitro experiment |
| Licorice Root | 📋 | ✍ | ⛔ | | 34676570 | Glycyrrhiza glabra alcoholic root extract ameliorates hyperglycemia, hyperlipidemia, and glycation-induced free iron-mediated oxidative reactions |
| Maitake Mushrooms | 📋 | | ⛔ | | 37193332 | Long-term consumption of different doses of Grifola frondosa affects immunity and metabolism: correlation with intestinal mucosal microbiota and blood lipids |
| Micronutrients | 📋 | | ⛔ | | 38145747 | A Historical, Evidence-Based, and Narrative Review on Commonly Used Dietary Supplements in Lipid-Lowering |
| Phytochemicals | 📋 | | | | 35391801 | Cholesterol-Lowering Phytochemicals: Targeting the Mevalonate Pathway for Anticancer Interventions |
| Rutin | 📋 | ✍ | ⛔ | | 37528147 | Influence of rutin and its combination with metformin on vascular functions in type 1 diabetes |
| Selenium | 📋 | ✍ | ⛔ | | 38258780 | The Effect of Selenium, Zinc, and their Combined Supplementation on Cardiometabolic Biomarkers-comparing their Effects in the Energy Restriction and High-fat Diet Methods in Obese Rats |
| Shiitake Mushrooms | 📋 | ✍ | ⛔ | | 34375514 | Effects of Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), Bars on Lipid and Antioxidant Profiles in Individuals with Borderline High Cholesterol: A Double-Blind Randomized Clinical Trial |
| Thymoquinone | 📋 | | ⛔ | | 37568105 | Protective role of thymoquinone in hyperlipidemia-induced liver injury in LDL-R-/-mice |
| Aged Garlic | 📋 | ✍ | ⛔ | | 36640154 | Effect of garlic extract on markers of lipid metabolism and inflammation in coronary artery disease (CAD) patients: A systematic review and meta-analysis |
| Aloe Vera | 📋 | ✍ | ⛔ | | 36481618 | Aloe vera in diabetic dyslipidemia: Improving blood glucose and lipoprotein levels in pre-clinical and clinical studies |
| Barley | 📋 | ✍ | ⛔ | | 37797689 | Highland barley attenuates high fat and cholesterol diet induced hyperlipidemia in mice revealed by 16S rRNA gene sequencing and untargeted metabolomics |
| Bee Propolis | 📋 | ✍ | ⛔ | | 34817371 | Preventive role of propolis against hyperglycemia and hyperlipidemia in Sprague dawley rats (Rattus norvegicus) animal modelling system |
| Beets | 📋 | ✍ | ⛔ | | 36837811 | Hypolipidemic Effects of Beetroot Juice in SHR-CRP and HHTg Rat Models of Metabolic Syndrome: Analysis of Hepatic Proteome |
| Blueberry | 📋 | ✍ | ⛔ | | 35564709 | Effects of Montmorency Tart Cherry and Blueberry Juice on Cardiometabolic and Other Health-Related Outcomes: A Three-Arm Placebo Randomized Controlled Trial |
| Cordyceps | 📋 | ✍ | ⛔ | | 37011745 | CM3-SII polysaccharide obtained from Cordyceps militaris ameliorates hyperlipidemia in heterozygous LDLR-deficient hamsters by modulating gut microbiota and NPC1L1 and PPARα levels |
| Evening Primrose Oil | 📋 | ✍ | ⛔ | | 32441049 | Effect of evening primrose oil supplementation on lipid profile: A systematic review and meta-analysis of randomized clinical trials |
| Flaxseed Oil | 📋 | ✍ | ⛔ | | 35721684 | The comparison of omega-3 and flaxseed oil on serum lipids and lipoproteins in hyperlipidemic male rats |
| Hydroxytyrosol | 📋 | | | | 35565844 | Oral Supplement Containing Hydroxytyrosol and Punicalagin Improves Dyslipidemia in an Adult Population without Co-Adjuvant Treatment: A Randomized, Double-Blind, Controlled and Crossover Trial |
| Naringenin | 📋 | ✍ | ⛔ | | 36555447 | Mechanism Underlying Naringenin Hypocholesterolemic Effects: Involvement of Estrogen Receptor α Subtype |
| Nobiletin | 📋 | ✍ | | | 36293338 | The Citrus Flavonoid Nobiletin Downregulates Angiopoietin-like Protein 3 (ANGPTL3) Expression and Exhibits Lipid-Modulating Effects in Hepatic Cells and Adult Zebrafish Models |
| Peanut | 📋 | | ⛔ | | 36782346 | Effects of the polypeptide from peanut meal mixed fermentation on lipid metabolism and intestinal flora of hyperlipidemic mice |
| Pine Bark | 📋 | ✍ | ⛔ | | 31855055 | Natural Polyphenols Improve Erectile Function and Lipid Profile in Patients Suffering From Erectile Dysfunction |
| Piperine | 📋 | ✍ | ⛔ | | 33492139 | Natural Piperine Improves Lipid Metabolic Profile of High-Fat Diet-Fed Mice by Upregulating SR-B1 and ABCG8 Transporters |
| Pterostilbene | 📋 | ✍ | ⛔ | | 31663469 | Effects of Pterostilbene on Diabetes, Liver Steatosis and Serum Lipids |
| Raspberry | 📋 | ✍ | ⛔ | | 38628181 | The effects of raspberry consumption on lipid profile and blood pressure in adults: A systematic review and meta-analysis |
| Taurine | 📋 | ✍ | ⛔ | | 38706565 | Untargeted metabolomics based on ultra-high performance liquid chromatography-mass spectrometry/MS reveals the lipid-lowering mechanism of taurine in hyperlipidemia mice |
| Turmeric | 📋 | ✍ | ⛔ | | 37230418 | Effects of curcumin/turmeric supplementation on lipid profile: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials |
| Allicin | 📋 | ✍ | ⛔ | | 38007734 | Effect of Grape Seed Procyanidins Combined with Allicin on Lipid Levels in Hyperlipidemic Rats |
| Apple Vinegar | 📋 | ✍ | ⛔ | | 34684574 | The Changes in Endogenous Metabolites in Hyperlipidemic Rats Treated with Herbal Mixture Containing Lemon, Apple Cider, Garlic, Ginger, and Honey |
| Arjuna | 📋 | ✍ | ⛔ | | 34919901 | Arjunolic acid downregulates elevated blood sugar and pro-inflammatory cytokines in streptozotocin (STZ)-nicotinamide induced type 2 diabetic rats |
| Ashwagandha | 📋 | ✍ | ⛔ | | 23930042 | Antidiabetic and antihyperlipidemic activity of hydroalcoholic extract of Withania coagulans Dunal dried fruit in experimental rat models |
| Black Pepper | 📋 | ✍ | ⛔ | | 35936152 | A Comparative Study on Clinical Evaluation of the Hypolipidemic Effects of Allium sativum, Trigonella foenum-graecum, Commiphora mukul, Picrorhiza kurroa, and Piper nigrum: A Pilot Study |
| Blackcurrant | 📋 | ✍ | ⛔ | | 37893207 | Blackcurrant Anthocyanins Improve Blood Lipids and Biomarkers of Inflammation and Oxidative Stress in Healthy Women in Menopause Transition without Changing Body Composition |
| Burdock | 📋 | | ⛔ | | 31195041 | Regulation of lipid metabolism in diabetic rats by Arctium lappa L. polysaccharide through the PKC/NF-κB pathway |
| Cardamom | 📋 | ✍ | ⛔ | | 28806968 | Cardamom powder supplementation prevents obesity, improves glucose intolerance, inflammation and oxidative stress in liver of high carbohydrate high fat diet induced obese rats |
| Chia Seeds | 📋 | | ⛔ | | 37456479 | The Effect of Chia Seeds on High-Density Lipoprotein (HDL) Cholesterol |
| Chlorella | 📋 | ✍ | ⛔ | | 35331862 | Effect of supplementation with Chlorella vulgaris on lipid profile in adults: a systematic review and dose-response meta-analysis of randomized controlled trials |
| Chrysin | 📋 | ✍ | ⛔ | | 35892244 | Chrysin reduces hypercholesterolemia-mediated atherosclerosis through modulating oxidative stress, microflora, and apoptosis in experimental rats |
| Coconut | 📋 | | ⛔ | | 38357247 | Effect of different forms of coconut on the lipid profile in normal free-living healthy subjects: A randomized controlled trial (Phase II) |
| Elderberry | 📋 | ✍ | ⛔ | | 30267603 | Long-Term Supplementation of Black Elderberries Promotes Hyperlipidemia, but Reduces Liver Inflammation and Improves HDL Function and Atherosclerotic Plaque Stability in Apolipoprotein E-Knockout Mice |
| Emodin | 📋 | | ⛔ | | 38286356 | Cholesterol-lowering effects of rhubarb free anthraquinones and their mechanism of action |
| Ferulic Acid | 📋 | ✍ | ⛔ | | 37446770 | Quercetin and Ferulic Acid Elicit Estrogenic Activities In Vivo and In Silico |
| Frankincense | 📋 | ✍ | ⛔ | | 30396086 | Polyphenol-rich Boswellia serrata gum prevents cognitive impairment and insulin resistance of diabetic rats through inhibition of GSK3β activity, oxidative stress and pro-inflammatory cytokines |
| Galangal | 📋 | ✍ | ⛔ | | 35488439 | Hypoglycemic, hypolipidemic and hepatoprotective effects of Alpinia officinarum on nicotinamide/streptozotocin induced type II diabetic rats |
| Ginkgo Biloba | 📋 | ✍ | ⛔ | | 36916480 | Effect of Ginkgo biloba extract on pharmacology and pharmacokinetics of atorvastatin in rats with hyperlipidaemia |
| Kiwifruit | 📋 | ✍ | ⛔ | | 32278604 | Consumption of two whole kiwifruit (Actinide chinensis) per day improves lipid homeostasis, fatty acid metabolism and gut microbiota in healthy rats |
| Krill Oil | 📋 | ✍ | ⛔ | | 36286433 | Krill Oil Inhibits Cholesterol Synthesis and Stimulated Cholesterol Excretion in Hypercholesterolemic Rats |
| Mango Leaf | 📋 | | ⛔ | | 28850305 | In Vitro Bioaccessibility and Effect of Mangifera indica (Ataulfo) Leaf Extract on Induced Dyslipidemia |
| Medicinal Plants | 📋 | | | | 36175900 | Medicinal and edible plants in the treatment of dyslipidemia: advances and prospects |
| MSM | 📋 | ✍ | ⛔ | | 35708633 | Methylsulfonylmethane and Sesame Seed Oil Improve Dyslipidemia and Modulate Polyunsaturated Fatty Acid Metabolism in Two Mouse Models of Diabetes |
| Myrrh | 📋 | ✍ | ⛔ | | 32197395 | Commiphora myrrha Resin Alcoholic Extract Ameliorates High Fat Diet Induced Obesity via Regulation of UCP1 and Adiponectin Proteins Expression in Rats |
| Naringin | 📋 | ✍ | ⛔ | | 36558166 | Extraction of Naringin from Pomelo and Its Therapeutic Potentials against Hyperlipidemia |
| Nattokinase | 📋 | ✍ | ⛔ | | 37836525 | The Effect of Nattokinase-Monascus Supplements on Dyslipidemia: A Four-Month Randomized, Double-Blind, Placebo-Controlled Clinical Trial |
| Nicotinamide | 📋 | ✍ | ⛔ | | 35222903 | Nicotinamide supplementation in diabetic nonalcoholic fatty liver disease patients: randomized controlled trial |
| Nuts | 📋 | | ⛔ | | 36771303 | Effects of Nut Consumption on Blood Lipids and Lipoproteins: A Comprehensive Literature Update |
| Oleuropein | 📋 | | | | 28347166 | Oleuropein improves glucose tolerance and lipid profile in rats with simultaneous renovascular hypertension and type 2 diabetes |
| Papaya | 📋 | ✍ | ⛔ | | 37457684 | Hypolipidaemic effects of papaya ( Carica papaya L.) juice on rats fed on a high fat and fructose diet |
| Plum | 📋 | | ⛔ | | 36721717 | Plum supplementation and lipid profile: a systematic review and meta-analysis of randomised controlled trials |
| Probiotics | 📋 | ✍ | ⛔ | | 37193478 | The Effects of Probiotics on Cholesterol Levels in Patients With Metabolic Syndrome: A Systematic Review |
| Puerarin | 📋 | ✍ | ⛔ | | 35052852 | Puerarin Attenuates Obesity-Induced Inflammation and Dyslipidemia by Regulating Macrophages and TNF-Alpha in Obese Mice |
| Pumpkin | 📋 | | ⛔ | | 35959224 | In Vitro Role of Pumpkin Parts as Pharma-Foods: Antihyperglycemic and Antihyperlipidemic Activities of Pumpkin Peel, Flesh, and Seed Powders, in Alloxan-Induced Diabetic Rats |
| Silibinin | 📋 | ✍ | | | 36077379 | Silibinin Suppresses the Hyperlipidemic Effects of the ALK-Tyrosine Kinase Inhibitor Lorlatinib in Hepatic Cells |
| Stevia | 📋 | ✍ | ⛔ | | 37677968 | Steviol glycosides from Stevia rebaudiana Bertoni mitigate lipid metabolism abnormalities in diabetes by modulating selected gene expression - An in vivo study |
| Sulforaphane | 📋 | ✍ | ⛔ | | 33833347 | Sulforaphane ameliorates lipid profile in rodents: an updated systematic review and meta-analysis |
| Tangeretin | 📋 | | | | 34576019 | The Lipid-Modulating Effect of Tangeretin on the Inhibition of Angiopoietin-like 3 (ANGPTL3) Gene Expression through Regulation of LXRα Activation in Hepatic Cells |
| Tetrahydrocurcumin | 📋 | ✍ | | | 26102010 | Effect of tetrahydrocurcumin on the profiles of drug-metabolizing enzymes induced by a high fat and high fructose diet in mice |
| Vitamin E | 📋 | ✍ | ⛔ | | 32529103 | A double-blind, placebo-controlled clinical trial to assess the effects of a combined nutraceutical on endothelial function in patients with mild-to-moderate hypercholesterolaemia |
| Aloe-Emodin | 📋 | | | | 38286356 | Cholesterol-lowering effects of rhubarb free anthraquinones and their mechanism of action |
| Andrographolide | 📋 | | | | 23844365 | Acute toxicity and the effect of andrographolide on Porphyromonas gingivalis-induced hyperlipidemia in rats |
| Apple Polyphenols | 📋 | | ⛔ | | 30646510 | A Boost in Mitochondrial Activity Underpins the Cholesterol-Lowering Effect of Annurca Apple Polyphenols on Hepatic Cells |
| Baicalein | 📋 | ✍ | ⛔ | | 34785144 | Baicalein alleviates pyroptosis and inflammation in hyperlipidemic pancreatitis by inhibiting NLRP3/Caspase-1 pathway through the miR-192-5p/TXNIP axis |
| Baicalin | 📋 | ✍ | ⛔ | | 35781653 | Dysregulated B7H4/JAK2/STAT3 Pathway Involves in Hypertriglyceridemia Acute Pancreatitis and Is Attenuated by Baicalin |
| Barberry | 📋 | ✍ | ⛔ | | 35255880 | The effect of barberry (Berberis integerrima) on lipid profile and systemic inflammation in subjects with cardiovascular risk factors: a randomized controlled trial |
| Basil | 📋 | ✍ | ⛔ | | 33995941 | Favorable effects of dill tablets and Ocimum basilicum L. extract on learning, memory, and hippocampal fatty acid composition in hypercholesterolemic rats |
| Basil Essential Oil | 📋 | ✍ | ⛔ | | 35591766 | Inhalation of low-dose basil (Ocimum basilicum) essential oil improved cardiovascular health and plasma lipid markers in high fat diet-induced obese rats |
| Bay Leaf | 📋 | | ⛔ | | 38597184 | Antihyperlipidemic effect and GC-MS analysis of phytoconstituents from Laurus nobilis essential oil in rat |
| Black Tea | 📋 | ✍ | ⛔ | | 36505232 | Sichuan dark tea improves lipid metabolism and prevents aortic lipid deposition in diet-induced atherosclerosis model rats |
| Blackberry | 📋 | | ⛔ | | 34617546 | Aqueous extracts of lingonberry and blackberry leaves identified by high-content screening beneficially act on cholesterol metabolism |
| Bladderwrack | 📋 | ✍ | ⛔ | | 38667804 | Exploring the Hypocholesterolemic Potential of a Fucus vesiculosus Extract: Omic Insights into Molecular Mechanisms at the Intestinal Level |
| Buckwheat | 📋 | | ⛔ | | 36215169 | Transcriptomic and Metabonomic Profiling Reveals the Antihyperlipidemic Effects of Tartary Buckwheat Sprouts in High-Fat-Diet-Fed Mice |
| Chaga Mushrooms | 📋 | ✍ | ⛔ | | 38628208 | Study of active components and mechanisms mediating the hypolipidemic effect of Inonotus obliquus polysaccharides |
| Chitosan | 📋 | ✍ | ⛔ | | 35366259 | Chitosan from Crabs ( Scylla serrata) Represses Hyperlipidemia-Induced Hepato-Renal Dysfunctions in Rats: Modulation of CD43 and p53 Expression |
| Chrysanthemum | 📋 | ✍ | ⛔ | | 36147301 | The hypolipidemic mechanism of chrysanthemum flavonoids and its main components, luteolin and luteoloside, based on the gene expression profile |
| Crocetin | 📋 | | | | 38386043 | Comparative pharmacokinetic investigation on crocetin in hyperlipidemia and normal rats after oral administration |
| Crocin | 📋 | ✍ | ⛔ | | 38617922 | Modulating effects of crocin on lipids and lipoproteins: Mechanisms and potential benefits |
| Diallyl Disulfide | 📋 | | | | 37138269 | Diallyl disulfide alleviates hypercholesterolemia induced by a western diet by suppressing endoplasmic reticulum stress in apolipoprotein E-deficient mice |
| Diosmin | 📋 | ✍ | ⛔ | | 35946912 | The Effect of Hesperidin and Diosmin Individually or in Combination on Metabolic Profile and Neuropathy among Diabetic Patients with Metabolic Syndrome: A Randomized Controlled Trial |
| Eucommia | 📋 | ✍ | ⛔ | | 38518640 | Aqueous extract of fermented Eucommia ulmoides leaves alleviates hyperlipidemia by maintaining gut homeostasis and modulating metabolism in high-fat diet fed rats |
| Fig | 📋 | | ⛔ | | 27086310 | Antihyperlipidemic and Antioxidant Activities of Edible Tunisian Ficus carica L. Fruits in High Fat Diet-Induced Hyperlipidemic Rats |
| Haritaki | 📋 | ✍ | ⛔ | | 35673508 | Effects of alcoholic extract of Terminalia Chebula dried fruit on blood biochemical profile in diabetic rats |
| Hazelnut | 📋 | | ⛔ | | 38043651 | Effects of hazelnut soluble dietary fiber on lipid-lowering and gut microbiota in high-fat-diet-fed rats |
| Hesperetin | 📋 | | | | 29080465 | Antihyperglycemic effect of hesperetin, a citrus flavonoid, extenuates hyperglycemia and exploring the potential role in antioxidant and antihyperlipidemic in streptozotocin-induced diabetic rats |
| Honey | 📋 | ✍ | ⛔ | | 36379223 | Effect of honey on cardiometabolic risk factors: a systematic review and meta-analysis |
| Jujube | 📋 | | ⛔ | | 35783519 | Jujuboside A Ameliorates Myocardial Apoptosis and Inflammation in Rats with Coronary Heart Disease by Inhibiting PPAR- α Signaling Pathway |
| Knotweed | 📋 | ✍ | ⛔ | | 36815210 | Ultra-high performance liquid chromatography- quadrupole/ time-of-flight mass spectrometry based lipidomics reveals key lipid molecules as potential therapeutic targets of Polygonum cuspidatum against hyperlipidemia in a hamster model |
| Lemon | 📋 | | ⛔ | | 34684574 | The Changes in Endogenous Metabolites in Hyperlipidemic Rats Treated with Herbal Mixture Containing Lemon, Apple Cider, Garlic, Ginger, and Honey |
| Lemon Balm | 📋 | ✍ | ⛔ | | 38575930 | Effects of Melissa officinalis (lemon balm) consumption on serum lipid profile: a meta-analysis of randomized controlled trials |
| Lipoic Acid | 📋 | ✍ | ⛔ | | 34605276 | Alpha lipoic acid supplementation affects serum lipids in a dose and duration-dependent manner in different health status |
| Loquat | 📋 | ✍ | ⛔ | | 37498560 | Polyphenol-rich extract from loquat fruit peel prevents hyperlipidemia and hepato-nephrotoxicity in mice: in vivo study and in silico prediction of possible mechanisms involving identified polyphenols and/or their circulating metabolites |
| Mangiferin | 📋 | | ⛔ | | 32941163 | Evaluation of efficacy of Bombax ceiba extract and its major constituent, mangiferin in streptozotocin (STZ)-induced diabetic rats |
| Milk Thistle | 📋 | ✍ | ⛔ | | 37183391 | Impact of Berberine or Berberine Combination Products on Lipoprotein, Triglyceride and Biological Safety Marker Concentrations in Patients with Hyperlipidemia: A Systematic Review and Meta-Analysis |
| Neem | 📋 | ✍ | | | 36521768 | EXPLORING the prophylactic potential of Azadirachta indica leaf extract against dyslipidemia |
| Persimmon | 📋 | | ⛔ | | 32115502 | Anti-obesity Effect of Fermented Persimmon Extracts via Activation of AMP-Activated Protein Kinase |
| Phytosterols | 📋 | | | | 37960208 | The Effect of Dietary Supplementation with Plant Sterols on Total and LDL-Cholesterol in Plasma Is Affected by Adherence to Mediterranean Diet: Insights from the DESCO Randomized Clinical Study |
| Poria Mushrooms | 📋 | ✍ | | | 38048892 | The anti-hyperlipidemic effects of Poria cocos (Schw.) Wolf extract: Modulating cholesterol homeostasis in hepatocytes via PPARα pathway |
| Proanthocyanidins | 📋 | | | | 38391003 | Effect of proanthocyanidins on blood lipids: A systematic review and meta-analysis |
| Pu-erh Tea | 📋 | ✍ | ⛔ | | 33598200 | Hypolipidemic, anti-inflammatory, and anti-atherosclerotic effects of tea before and after microbial fermentation |
| Pumpkin Seed | 📋 | ✍ | ⛔ | | 23983330 | The effect of pumpkin (Cucurbita pepo L) seeds and L-arginine supplementation on serum lipid concentrations in atherogenic rats |
| Rice | 📋 | | ⛔ | | 36948432 | Black rice regulates lipid metabolism, liver injury, oxidative stress and adipose accumulation in high-fat/cholesterol diet mice based on gut microbiota and untargeted metabonomics |
| Rosemary Essential Oil | 📋 | ✍ | ⛔ | | 31353725 | Ameliorative impact of cold-pressed Rosmarinus officinalis oil against liver toxicity and genotoxic effects in streptozotocin-induced diabetic rats and their offspring |
| Salidroside | 📋 | | | | 33341055 | Salidroside simultaneously reduces de novo lipogenesis and cholesterol biosynthesis to attenuate atherosclerosis in mice |
| Schisandra | 📋 | ✍ | ⛔ | | 32952590 | Schisandra Fruit Vinegar Lowers Lipid Profile in High-Fat Diet Rats |
| Sesamin | 📋 | ✍ | | | 35396857 | Comparative effects of sesame lignans (sesamin, sesamolin, and sesamol) on oxidative stress and lipid metabolism in steatosis HepG2 cells |
| Sesamol | 📋 | | | | 37110801 | Hypolipidemic and Anti-Atherogenic Effects of Sesamol and Possible Mechanisms of Action: A Comprehensive Review |
| Stinging Nettle | 📋 | ✍ | ⛔ | | 38571539 | Inhibitory effect of stinging nettle (Urtica dioica L.) extract on body weight gain in rats on a high-fat diet |
| Tomato | 📋 | | ⛔ | | 32243013 | Effect of tomato consumption on fasting blood glucose and lipid profiles: A systematic review and meta-analysis of randomized controlled trials |
| Zeaxanthin | 📋 | ✍ | ⛔ | | 36336325 | The effect of lutein and Zeaxanthine on Dyslipidemia: A meta-analysis study |
| Acetyl-L-Carnitine | 📋 | ✍ | ⛔ | | 31945029 | Anti-Inflammatory and Antioxidant Effects of Acetyl-L-Carnitine on Atherosclerotic Rats |
| Almond Oil | 📋 | | ⛔ | | 30670262 | Almond oil for patients with hyperlipidemia: A randomized open-label controlled clinical trial |
| Alpha-Linolenic Acid | 📋 | ✍ | ⛔ | | 35107625 | Peony seed oil decreases plasma cholesterol and favorably modulates gut microbiota in hypercholesterolemic hamsters |
| Amaranth | 📋 | | ⛔ | | 35796287 | Multigrain porridge possesses superior nutritional quality, its consumption alleviates hyperglycemia, hypercholesterolemia and oxidative stress in obese-diabetic wistar rats |
| Andrographis | 📋 | ✍ | ⛔ | | 33225300 | Hypoglycemic Effect of a Combined Andrographis paniculata and Caesalpinia sappan Extract in Streptozocin-Induced Diabetic Rats |
| Anethole | 📋 | | | | 37457161 | Cookies enriched with anethole and secoisolariciresinol diglucoside from flaxseed and fennel seeds improve hypercholesterolemia, lipid profile, and liver functions: A pilot study |
| Antioxidants | 📋 | | ⛔ | | 38487634 | Linear association of compound dietary antioxidant index with hyperlipidemia: a cross-sectional study |
| Astragalus Root | 📋 | ✍ | ⛔ | | 37824046 | Astragalus polysaccharide alleviates polycystic ovary syndrome by reducing insulin resistance and oxidative stress and increasing the diversity of gut microbiota |
| Beer | 📋 | | | | 37402233 | Effect of moderate beer consumption (with and without ethanol) on cardiovascular health in postmenopausal women |
| Betaine | 📋 | ✍ | ⛔ | | 38667581 | Low Dietary Betaine Intake Is Associated with Increased Blood Cholesterol in Mexican Subjects |
| Biochanin A | 📋 | | | | 34276221 | Biochanin A Regulates Cholesterol Metabolism Further Delays the Progression of Nonalcoholic Fatty Liver Disease |
| Black Tea Polyphenols | 📋 | | | | 29592809 | Exploring the potential of black tea based flavonoids against hyperlipidemia related disorders |
| Boswellic Acid | 📋 | ✍ | ⛔ | | 35121344 | Anti-diabetic potential of β-boswellic acid and 11-keto-β-boswellic acid: Mechanistic insights from computational and biochemical approaches |
| Bromelain | 📋 | ✍ | ⛔ | | 37749825 | Protective effect of bromelain on some metabolic enzyme activities in tyloxapol-induced hyperlipidemic rats |
| Caffeine | 📋 | ✍ | ⛔ | | 35633414 | Comparative and Combined Effects of Epigallocatechin-3-gallate and Caffeine in Reducing Lipid Accumulation in Caenorhabditis elegans |
| Catechins | 📋 | | | | 38034724 | Effects of green tea catechin on the blood pressure and lipids in overweight and obese population-a meta-analysis |
| Cherry | 📋 | | ⛔ | | 35564709 | Effects of Montmorency Tart Cherry and Blueberry Juice on Cardiometabolic and Other Health-Related Outcomes: A Three-Arm Placebo Randomized Controlled Trial |
| Cinnamaldehyde | 📋 | | | | 35774377 | Cinnamaldehyde Mitigates Atherosclerosis Induced by High-Fat Diet via Modulation of Hyperlipidemia, Oxidative Stress, and Inflammation |
| Citrus Fruits | 📋 | | ⛔ | | 35237168 | Citrus Extract as a Perspective for the Control of Dyslipidemia: A Systematic Review With Meta-Analysis From Animal Models to Human Studies |
| Coconut Protein | 📋 | | | | 15274481 | Influence of Coconut Kernel Protein on Lipid Metabolism in Alcohol Fed Rats |
| Coriander | 📋 | | ⛔ | | 33477662 | Antioxidant, Anti-Inflammatory and Antidiabetic Proprieties of LC-MS/MS Identified Polyphenols from Coriander Seeds |
| Diosgenin | 📋 | | | | 34552341 | The Effects of Diosgenin on Hypolipidemia and Its Underlying Mechanism: A Review |
| Eicosapentaenoic Acid | 📋 | ✍ | ⛔ | | 32636128 | Administration of Eicosapentaenoic Acid May Alter Lipoprotein Particle Heterogeneity in Statin-Treated Patients With Stable Coronary Artery Disease: A Pilot 6-month Randomized Study |
| Fisetin | 📋 | ✍ | ⛔ | | 38129008 | Fisetin, a dietary flavonoid, promotes transintestinal cholesterol excretion through the activation of PPARδ |
| Fo-Ti Root | 📋 | ✍ | ⛔ | | 29093330 | The Anti-hyperlipidemia Effects of Raw Polygonum multiflorum Extract in Vivo |
| Gallic Acid | 📋 | | ⛔ | | 32401050 | New insights into the in vitro, in situ and in vivo antihyperglycemic mechanisms of gallic acid and p-coumaric acid |
| Gingerol | 📋 | ✍ | | | 26493465 | Ameliorative potential of gingerol: Promising modulation of inflammatory factors and lipid marker enzymes expressions in HFD induced obesity in rats |
| Guava | 📋 | | ⛔ | | 30854003 | High Carbohydrate High Fat Diet Induced Hepatic Steatosis and Dyslipidemia Were Ameliorated by Psidium guajava Leaf Powder Supplementation in Rats |
| Guggulsterone | 📋 | | | | 38089157 | Effect of dietary supplementation with a new nutraceutical formulation on cardiometabolic risk factors: a double-blind, placebo-controlled, randomized clinical study |
| Gymnema Sylvestre | 📋 | ✍ | ⛔ | | 38137721 | Combined Inositols, α-Lactalbumin, Gymnema Sylvestre and Zinc Improve the Lipid Metabolic Profile of Patients with Type 2 Diabetes Mellitus: A Randomized Clinical Trial |
| Icariin | 📋 | ✍ | | | 34906049 | AMPK/PGC-1α/GLUT4-Mediated Effect of Icariin on Hyperlipidemia-Induced Non-Alcoholic Fatty Liver Disease and Lipid Metabolism Disorder in Mice |
| Indian Barberry | 📋 | ✍ | ⛔ | | 31784970 | The Effects of a Fixed Combination of Berberis aristata and Silybum marianum on Dyslipidaemia - A Meta-analysis and Systematic Review |
| Inulin | 📋 | ✍ | ⛔ | | 34401107 | Assessing the effects of inulin-type fructan intake on body weight, blood glucose, and lipid profile: A systematic review and meta-analysis of randomized controlled trials |
| Isoflavones | 📋 | ✍ | ⛔ | | 38569436 | Dietary isoflavone intake is inversely associated with remnant cholesterol in US adults: A cross-sectional study |
| L-Carnosine | 📋 | ✍ | ⛔ | | 36808356 | Antihyperlipidemic potential of dietary supplementation with carnosine in high-fat diet-fed rats |
| Ligustilide | 📋 | | | | 37579692 | Ligustilide covalently binds to Cys129 of HMGCS1 to ameliorate dyslipidemia |
| Lingonberry | 📋 | | ⛔ | | 34617546 | Aqueous extracts of lingonberry and blackberry leaves identified by high-content screening beneficially act on cholesterol metabolism |
| Lutein | 📋 | ✍ | ⛔ | | 36336325 | The effect of lutein and Zeaxanthine on Dyslipidemia: A meta-analysis study |
| Myrtle | 📋 | ✍ | ⛔ | | 37566463 | Myrtle Berries Seeds Prevent Dyslipidemia, Inflammation, and Excessive Cardiac Reactive Oxygen Species Production in Response to High-Fat Diet-Induced Obesity |
| Nuciferine | 📋 | | | | 37186242 | Nuciferine blocks MIB2-mediated CARD6 polyubiquitination and degradation in the amelioration of high fructose-induced liver lipid accumulation |
| Oleic Acid | 📋 | | ⛔ | | 32724624 | High dietary oleic acid in olive oil-supplemented diet enhanced omega-3 fatty acid in blood plasma of rats |
| Onion | 📋 | ✍ | ⛔ | | 34262717 | Effect of onion on blood lipid profile: A meta-analysis of randomized controlled trials |
| Oolong Tea | 📋 | | ⛔ | | 29419789 | Aged Oolong Tea Reduces High-Fat Diet-Induced Fat Accumulation and Dyslipidemia by Regulating the AMPK/ACC Signaling Pathway |
| Oyster Mushrooms | 📋 | | ⛔ | | 38472823 | Exploring Therapeutic Potential of Pleurotus ostreatus and Agaricus bisporus Mushrooms against Hyperlipidemia and Oxidative Stress Using Animal Model |
| Paeoniflorin | 📋 | | | | 36081948 | Paeoniflorin alleviates liver injury in hypercholesterolemic rats through the ROCK/AMPK pathway |
| Pineapple | 📋 | ✍ | ⛔ | | 36062986 | Pineapple fruit improves vascular endothelial dysfunction, hepatic steatosis, and cholesterol metabolism in rats fed a high-cholesterol diet |
| Pomegranate Seed extract | 📋 | | ⛔ | | 31117552 | Hypocholesterolemic Effects of Expeller-Pressed and Solvent-Extracted Fruit Seed Oils and Defatted Pomegranate Seed Meals |
| Procyanidins | 📋 | | ⛔ | | 30646510 | A Boost in Mitochondrial Activity Underpins the Cholesterol-Lowering Effect of Annurca Apple Polyphenols on Hepatic Cells |
| PUFA | 📋 | | | | 38613089 | Improvement in Visceral Adipose Tissue and LDL Cholesterol by High PUFA Intake: 1-Year Results of the NutriAct Trial |
| Pumpkin Seed Oil | 📋 | ✍ | ⛔ | | 26405765 | Replacement of Dietary Saturated Fat by PUFA-Rich Pumpkin Seed Oil Attenuates Non-Alcoholic Fatty Liver Disease and Atherosclerosis Development, with Additional Health Effects of Virgin over Refined Oil |
| Rapeseed Oil | 📋 | ✍ | | | 37740067 | Effects of rapeseed oil on body composition and glucolipid metabolism in people with obesity and overweight: a systematic review and meta-analysis |
| Royal Jelly | 📋 | ✍ | ⛔ | | 35325025 | Royal jelly fatty acids downregulate ANGPTL8 expression through the decrease in HNF4α protein in human hepatoma HepG2 cells |
| Seaweeds | 📋 | | ⛔ | | 38410655 | Hypolipidemic effect of brown seaweed ( Sargassum crassifolium) extract in vivo (Study of histopathology, mRNA expression, and immunohistochemistry (IHC) with VCAM-1, ICAM-1, and MCP-1 parameters) |
| Sesame | 📋 | ✍ | ⛔ | | 38316576 | Effect of sesame supplementation on body composition and lipid profile in patients with type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials |
| Sesame Oil | 📋 | | ⛔ | | 35708633 | Methylsulfonylmethane and Sesame Seed Oil Improve Dyslipidemia and Modulate Polyunsaturated Fatty Acid Metabolism in Two Mouse Models of Diabetes |
| Skullcap | 📋 | ✍ | ⛔ | | 38677575 | Mechanism of the components compatibility of Scutellariae Radix and Coptidis Rhizoma on mice with hyperlipidemia by regulating the Cyp4a family |
| Soy Isoflavones | 📋 | ✍ | ⛔ | | 34444691 | Effects of Soy Protein Containing of Isoflavones and Isoflavones Extract on Plasma Lipid Profile in Postmenopausal Women as a Potential Prevention Factor in Cardiovascular Diseases: Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| Soy Protein | 📋 | ✍ | ⛔ | | 38174000 | Protein supplementation: the double-edged sword |
| Spikenard | 📋 | ✍ | ⛔ | | 28690119 | Cholesterol-lowering effect of Aralia elata (Miq.) Seem via the activation of SREBP-2 and the LDL receptor |
| St. Johns Wort | 📋 | ✍ | ⛔ | | 33383372 | Improvements in estrogen deficiency-induced hypercholesterolemia by Hypericum perforatum L. extract are associated with gut microbiota and related metabolites in ovariectomized (OVX) rats |
| Star Anise | 📋 | ✍ | ⛔ | | 30700011 | Hypolipogenic Effect of Shikimic Acid Via Inhibition of MID1IP1 and Phosphorylation of AMPK/ACC |
| Sweet Potato | 📋 | | ⛔ | | 34639164 | Potential Effects of Sweet Potato ( Ipomoea batatas) in Hyperglycemia and Dyslipidemia-A Systematic Review in Diabetic Retinopathy Context |
| Tannic Acid | 📋 | ✍ | ⛔ | | 34967286 | Dietary Intake of Hydrolyzable Tannins and Condensed Tannins to Regulate Lipid Metabolism |
| Tea | 📋 | | | | 36395969 | Research Progress on the Lipid-Lowering and Weight Loss Effects of Tea and the Mechanism of its Functional Components |
| Theabrownins | 📋 | | | | 35088787 | Theabrownin-targeted regulation of intestinal microorganisms to improve glucose and lipid metabolism in Goto-Kakizaki rats |
| Vitamin B6 | 📋 | ✍ | ⛔ | | 36183668 | Selenium and vitamin B6 cosupplementation improves dyslipidemia and fatty liver syndrome by SIRT1/SREBP-1c pathway in hyperlipidemic Sprague-Dawley rats induced by high-fat diet |
| Vitamin K2 | 📋 | ✍ | ⛔ | | 36696048 | Co-supplementation of Vitamin K2 and Selenium Synergistically Improves Metabolic Status and Reduces Cardiovascular Risk Markers in Dyslipidemic Rabbits |
| White Mushrooms | 📋 | | ⛔ | | 38472823 | Exploring Therapeutic Potential of Pleurotus ostreatus and Agaricus bisporus Mushrooms against Hyperlipidemia and Oxidative Stress Using Animal Model |
| Wine | 📋 | | ⛔ | | 37254366 | Cabernet sauvignon dry red wine ameliorates atherosclerosis in mice by regulating inflammation and endothelial function, activating AMPK phosphorylation, and modulating gut microbiota |
| Withaferin A | 📋 | | | | 35734936 | Modulatory action of withaferin-A on oxidative damage through regulation of inflammatory mediators and apoptosis via PI3K/AKT signaling pathway in high cholesterol-induced atherosclerosis in experimental rats |
| Zinc | 📋 | ✍ | ⛔ | | 38258780 | The Effect of Selenium, Zinc, and their Combined Supplementation on Cardiometabolic Biomarkers-comparing their Effects in the Energy Restriction and High-fat Diet Methods in Obese Rats |
| Alfalfa | 📋 | | ⛔ | | 31210545 | Effects of estrogen deficiency on liver function and uterine development: assessments of Medicago sativa's activities as estrogenic, anti-lipidemic, and antioxidant agents using an ovariectomized mouse model |
| Apricot Kernels | 📋 | ✍ | ⛔ | | 35055679 | Phytonutrients of Bitter Apricot Seeds Modulate Human Lipid Profile and LDL Subfractions in Adults with Elevated Cholesterol Levels |
| Asafoetida | 📋 | ✍ | ⛔ | | 30471513 | Antidiabetic and antihyperlipidemic effects of ethanolic Ferula assa-foetida oleo-gum-resin extract in streptozotocin-induced diabetic wistar rats |
| Ashitaba | 📋 | ✍ | ⛔ | | 36235163 | Assessment of the Hypoglycemic and Hypolipidemic Activity of Flavonoid-Rich Extract from Angelica keiskei |
| Asiatic Acid | 📋 | | | | 24075211 | Antidiabetic and antihyperlipidemic activity of asiatic acid in diabetic rats, role of HMG CoA: in vivo and in silico approaches |
| Asparagus | 📋 | | ⛔ | | 36313282 | Asparagus cochinchinensis alleviates disturbances of lipid metabolism and gut microbiota in high-fat diet-induced obesity mice |
| Aspirin | 📋 | | ⛔ | | 36175048 | Aspirin for Primary Prevention of Cardiovascular Events in Relation to Lipoprotein(a) Genotypes |
| Astragalosides | 📋 | ✍ | ⛔ | | 33706619 | Treatment with astragaloside IV reduced blood glucose, regulated blood lipids, and protected liver function in diabetic rats |
| Atractylodes | 📋 | ✍ | ⛔ | | 38560167 | The anti-hyperlipidemia effect of Atractylodes macrocephala Rhizome increased HDL via reverse cholesterol transfer |
| Avocado Oil | 📋 | | ⛔ | | 30051518 | Effect of virgin avocado oil on diet-induced hypercholesterolemia in rats via 1 H NMR-based metabolomics approach |
| Banana | 📋 | | ⛔ | | 27339779 | Effects of a Combined Nutraceutical on Lipid Pattern, Glucose Metabolism and Inflammatory Parameters in Moderately Hypercholesterolemic Subjects: A Double-blind, Cross-over, Randomized Clinical Trial |
| BCAA | 📋 | ✍ | ⛔ | | 33807510 | Hypolipemiant Actions and Possible Cardioprotective Effects of Valine and Leucine: An Experimental Study |
| Bean | 📋 | | ⛔ | | 36444040 | Polysaccharides from red kidney bean alleviating hyperglycemia and hyperlipidemia in type 2 diabetic rats via gut microbiota and lipid metabolic modulation |
| Bee Pollen | 📋 | ✍ | ⛔ | | 33288184 | Effect of antioxidant-rich propolis and bee pollen extracts against D-glucose induced type 2 diabetes in rats |
| Bergamot Essential Oil | 📋 | ✍ | ⛔ | | 30501605 | Hypoglycemic and Hypolipemic Effects of a New Lecithin Formulation of Bergamot Polyphenolic Fraction: A Double Blind, Randomized, Placebo- Controlled Study |
| Beta-Sitosterol | 📋 | ✍ | ⛔ | | 24364088 | [Addition of pomegranate juice to statin inhibits cholesterol accumulation in macrophages: protective role for the phytosterol beta-sitosterol and for the polyphenolic antioxidant punicalagin] |
| Bitter Melon | 📋 | ✍ | ⛔ | | 35507955 | Effect of Momordica charantia Administration on Anthropometric Measures and Metabolic Profile in Patients with Obesity: A Pilot Clinical Trial |
| Butyrate | 📋 | | ⛔ | | 36555149 | Butyrate Lowers Cellular Cholesterol through HDAC Inhibition and Impaired SREBP-2 Signalling |
| Cabbage | 📋 | | ⛔ | | 36866218 | The protective effect of red cabbage on water-soluble fractions of spent crankcase oil-induced alterations in lipid function biomarkers and atherogenic indices in male Albino rats |
| Caffeic Acid | 📋 | ✍ | ⛔ | | 36979705 | Potential of Caffeic Acid and 10-Dehydrogingerdione as Lipid Regulators Relevant to Their Inhibitory Effect on miR-122 and ATP Citrate Lyase Activity in Diabetic Hyperlipidemic Rats |
| Calcium | 📋 | ✍ | ⛔ | | 27870724 | The Effects of Dietary Calcium Supplements Alone or With Vitamin D on Cholesterol Metabolism: A Meta-Analysis of Randomized Controlled Trials |
| Cantaloupe | 📋 | | ⛔ | | 36418190 | Cucumis melo seed oil: Agro-food by-product with natural anti-hyperlipidemic potential |
| Capsanthin | 📋 | | | | 35892680 | Capsanthin Inhibits Atherosclerotic Plaque Formation and Vascular Inflammation in ApoE -/- Mice |
| Carvacrol | 📋 | ✍ | ⛔ | | 38154959 | Carvacrol improves blood lipid and glucose in rats with type 2 diabetes mellitus by regulating short-chain fatty acids and the GPR41/43 pathway |
| Cat's Claw | 📋 | ✍ | ⛔ | | 35260150 | GlucoMedix®, an extract of Stevia rebaudiana and Uncaria tomentosa, reduces hyperglycemia, hyperlipidemia, and hypertension in rat models without toxicity: a treatment for metabolic syndrome |
| Celery | 📋 | | ⛔ | | 35536382 | Safety evaluation and biochemical efficacy of celery seed extract (Apium Graveolens) capsules in hypertensive patients: a randomized, triple-blind, placebo-controlled, cross-over, clinical trial |
| Chamomile | 📋 | ✍ | ⛔ | | 28056419 | Chamomile (Matricaria recutita L.) decoction extract inhibits in vitro intestinal glucose absorption and attenuates high fat diet-induced lipotoxicity and oxidative stress |
| Cheese | 📋 | | ⛔ | | 35503897 | Cheese Intake is Inversely Associated with LDL Cholesterol in Young Children |
| Chickpea | 📋 | | ⛔ | | 35938733 | Ameliorative effects of chickpea flavonoids on redox imbalance and mitochondrial complex I dysfunction in type 2 diabetic rats |
| Chicory | 📋 | ✍ | ⛔ | | 35228184 | A randomized controlled trial on albino rats treated with chicory plant to improve liver efficiency |
| Choline | 📋 | ✍ | ⛔ | | 36973700 | Dietary choline and betaine intake, cardio-metabolic risk factors and prevalence of metabolic syndrome among overweight and obese adults |
| Citron | 📋 | | ⛔ | | 34710667 | Structurally diverse biflavonoids from the fruits of Citrus medica L. var. sarcodactylis Swingle and their hypolipidemic and immunosuppressive activities |
| Conjugated Linoleic Acid | 📋 | ✍ | ⛔ | | 36438733 | The effects of conjugated linoleic acid supplementation on lipid profile in adults: A systematic review and dose-response meta-analysis |
| Corn | 📋 | | ⛔ | | 30204921 | Corn Oil Lowers Plasma Cholesterol Compared with Coconut Oil in Adults with Above-Desirable Levels of Cholesterol in a Randomized Crossover Trial |
| Corn Silk | 📋 | ✍ | ⛔ | | 35978956 | Modulation of gut microbiota and fecal metabolites by corn silk among high-fat diet-induced hypercholesterolemia mice |
| Cumin | 📋 | | ⛔ | | 34328087 | Supplementation of cumin seed powder prevents oxidative stress, hyperlipidemia and non-alcoholic fatty liver in high fat diet fed rats |
| Cyanidin | 📋 | ✍ | | | 28215316 | Aronia berry polyphenol consumption reduces plasma total and low-density lipoprotein cholesterol in former smokers without lowering biomarkers of inflammation and oxidative stress: a randomized controlled trial |
| Daidzein | 📋 | ✍ | ⛔ | | 33899670 | Dietary isoflavones intake is inversely associated with non-alcoholic fatty liver disease, hyperlipidaemia and hypertension |
| Dandelion | 📋 | ✍ | ⛔ | | 20162002 | Hypolipidemic and antioxidant effects of dandelion (Taraxacum officinale) root and leaf on cholesterol-fed rabbits |
| Delphinidin | 📋 | | | | 34281481 | Delphinidin-3-sambubioside from Hibiscus sabdariffa. L attenuates hyperlipidemia in high fat diet-induced obese rats and oleic acid-induced steatosis in HepG2 cells |
| Dihydroartemisinin | 📋 | | | | 34847494 | Dihydroartemisinin improves hypercholesterolemia in ovariectomized mice via enhancing vectorial transport of cholesterol and bile acids from blood to bile |
| Dihydromyricetin | 📋 | ✍ | ⛔ | | 35147634 | Dihydromyricetin prevents obesity via regulating bile acid metabolism associated with the farnesoid X receptor in ob/ ob mice |
| Diosmetin | 📋 | | | | 33282249 | Comparative study of the effects of diosmin and diosmetin on fat accumulation, dyslipidemia, and glucose intolerance in mice fed a high-fat high-sucrose diet |
| Docosahexaenoic Acid | 📋 | ✍ | ⛔ | | 19277604 | n-3 fatty acids and rosiglitazone improve insulin sensitivity through additive stimulatory effects on muscle glycogen synthesis in mice fed a high-fat diet |
| Equol | 📋 | ✍ | ⛔ | | 34749871 | [Lipids-lowering effects of equol on low density lipoprotein receptor knockout hamsters] |
| Eugenol | 📋 | | | | 31570745 | Eugenol Reduces LDL Cholesterol and Hepatic Steatosis in Hypercholesterolemic Rats by Modulating TRPV1 Receptor |
| Fat | 📋 | | | | 35617705 | Partial Replacement of High-Fat Diet with Beef Tallow Attenuates Dyslipidemia and Endoplasmic Reticulum Stress in db/ db Mice |
| Fennel | 📋 | ✍ | ⛔ | | 37457161 | Cookies enriched with anethole and secoisolariciresinol diglucoside from flaxseed and fennel seeds improve hypercholesterolemia, lipid profile, and liver functions: A pilot study |
| Fennel Essential Oil | 📋 | ✍ | ⛔ | | 30417995 | Health Benefits of Fennel, Rosemary Volatile Oils and their Nano-Forms in Dyslipidemic Rat Model |
| Fluted Gourd | 📋 | | | | 34987254 | Anti-hyperlipidemic and antioxidant potentials of aqueous leaf extract of Telfairia occidentalis (fluted pumpkin) in male Sprague-Dawley rats |
| Folate | 📋 | ✍ | ⛔ | | 36859278 | The associations of dietary folate and serum folate with lipid profiles: findings from the national health and nutrition examination survey 2011-2016 |
| Formononetin | 📋 | | | | 22084061 | Red clover extract ameliorates dyslipidemia in streptozotocin-induced diabetic C57BL/6 mice by activating hepatic PPARα |
| Forskolin | 📋 | ✍ | ⛔ | | 34104650 | Synergetic Action of Forskolin and Mevastatin Induce Normalization of Lipids Profile in Dyslipidemic Rats through Adenosine Monophosphate Kinase Upregulation |
| Fucoxanthin | 📋 | ✍ | ⛔ | | 27406217 | Fucoxanthin Suppresses Lipid Accumulation and ROS Production During Differentiation in 3T3-L1 Adipocytes |
| GABA | 📋 | ✍ | ⛔ | | 38256069 | Anti-Obesity Effects of GABA in C57BL/6J Mice with High-Fat Diet-Induced Obesity and 3T3-L1 Adipocytes |
| Ganoderic Acid | 📋 | | | | 32686808 | Ganoderic acid A from Ganoderma lucidum ameliorates lipid metabolism and alters gut microbiota composition in hyperlipidemic mice fed a high-fat diet |
| Garlic Oil | 📋 | | ⛔ | | 35531198 | Obviation of dyslipidemia by garlic oil and its organosulfur compound, diallyl disulphide, in experimental animals |
| Ginger Essential Oil | 📋 | ✍ | | | 28638882 | POSSIBLE HYPOCHOLESTEROLEMIC EFFECT OF GINGER AND ROSEMARY OILS IN RATS |
| Gotu Kola | 📋 | ✍ | ⛔ | | 32526339 | Lei-gong-gen formula granule attenuates hyperlipidemia in rats via cGMP-PKG signaling pathway |
| Grape Seed Oil | 📋 | | ⛔ | | 31117552 | Hypocholesterolemic Effects of Expeller-Pressed and Solvent-Extracted Fruit Seed Oils and Defatted Pomegranate Seed Meals |
| Grapefruit | 📋 | | ⛔ | | 27134462 | Antihyperlipidemic effects of Citrus sinensis, Citrus paradisi, and their combinations |
| Grapefruit Essential Oil | 📋 | ✍ | ⛔ | | 32760938 | Dietary citrus peel essential oil ameliorates hypercholesterolemia and hepatic steatosis by modulating lipid and cholesterol homeostasis |
| Grapefruit extract | 📋 | ✍ | ⛔ | | 19391322 | Hypoglycemic and hypolipidemic effects of methanol seed extract of Citrus paradisi Macfad (Rutaceae) in alloxan-induced diabetic Wistar rats |
| Haskap | 📋 | | | | 34439452 | Antioxidant Effect of Lonicera caerulea L. in the Cardiovascular System of Obese Zucker Rats |
| Holy Basil | 📋 | ✍ | ⛔ | | 25646044 | Antidyslipidemic Effect of Ocimum sanctum Leaf Extract in Streptozotocin Induced Diabetic Rats |
| Icaritin | 📋 | | | | 33673187 | The Cholesterol-Lowering Effect of Capsella Bursa-Pastoris Is Mediated via SREBP2 and HNF-1α-Regulated PCSK9 Inhibition in Obese Mice and HepG2 Cells |
| Isoliquiritigenin | 📋 | | | | 36364321 | Inhibitory Effect of Isoliquiritigenin in Niemann-Pick C1-Like 1-Mediated Cholesterol Uptake |
| Isoquercitrin | 📋 | | | | 33219537 | Effect of the polyphenol-rich extract from Allium cepa on hyperlipidemic sprague-dawley rats |
| Isorhamnetin | 📋 | | | | 32918994 | Network pharmacology analysis and experimental validation to explore the mechanism of sea buckthorn flavonoids on hyperlipidemia |
| Kacip Fatimah | 📋 | ✍ | ⛔ | | 27288916 | Effects of Labisia pumila var alata extracts on the lipid profile, serum antioxidant status and abdominal aorta of high-cholesterol diet rats |
| Kaempferol | 📋 | ✍ | ⛔ | | 34279554 | Kaempferol ameliorates symptoms of metabolic syndrome by improving blood lipid profile and glucose tolerance |
| Kale | 📋 | | | | 34432833 | Kale supplementation during high fat feeding improves metabolic health in a mouse model of obesity and insulin resistance |
| Kudzu Root | 📋 | ✍ | ⛔ | | 28840970 | Evaluating Efficacy and Safety of Combination Medication of Atorvastatin and a Herbal Formula Containing Salvia miltiorrhiza and Pueraria lobata on Hyperlipidemia |
| L-Glutamine | 📋 | ✍ | ⛔ | | 34653558 | l-Glutamine supplementation enhances glutathione peroxidase and paraoxonase-1 activities in HDL of exercising older individuals |
| Laminaria | 📋 | ✍ | ⛔ | | 37702045 | Fucogalactan Sulfate (FS) from Laminaria japonica Regulates Lipid Metabolism in Diet-Induced Humanized Dyslipidemia Mice via an Intestinal FXR-FGF19-CYP7A1/CYP8B1 Pathway |
| Lauric Acid | 📋 | ✍ | | | 27679437 | In Silico and Wet Lab Studies Reveal the Cholesterol Lowering Efficacy of Lauric Acid, a Medium Chain Fat of Coconut Oil |
| Lavender | 📋 | ✍ | ⛔ | | 32291194 | The effect of aqueous extract of Lavandula officinalis to reduce cholesterol, triglyceride and other lipid metabolites on female BALB/c mice |
| Lemon Balm Essential Oil | 📋 | ✍ | ⛔ | | 22279139 | Melissa officinalis essential oil reduces plasma triglycerides in human apolipoprotein E2 transgenic mice by inhibiting sterol regulatory element-binding protein-1c-dependent fatty acid synthesis |
| Lemon Essential Oil | 📋 | ✍ | ⛔ | | 32760938 | Dietary citrus peel essential oil ameliorates hypercholesterolemia and hepatic steatosis by modulating lipid and cholesterol homeostasis |
| Lemon Verbena | 📋 | | ⛔ | | 32520695 | Antihyperglycemic and Antihyperlipidemic Effects of Lippia citriodora in Rats |
| Lentil | 📋 | | ⛔ | | 38337705 | Twelve Weeks of Daily Lentil Consumption Improves Fasting Cholesterol and Postprandial Glucose and Inflammatory Responses-A Randomized Clinical Trial |
| Licochalcones | 📋 | | | | 21840191 | Licochalcone E has an antidiabetic effect |
| Lime Essential Oil | 📋 | ✍ | ⛔ | | 31500259 | Lime ( Citrus aurantifolia (Christm.) Swingle) Essential Oils: Volatile Compounds, Antioxidant Capacity, and Hypolipidemic Effect |
| Limonin | 📋 | | | | 38375746 | Limonin alleviates high-fat diet-induced dyslipidemia by regulating the intestinal barrier via the microbiota-related ILC3-IL22-IL22R pathway |
| Linalool | 📋 | | ⛔ | | 35565791 | Olfactory Stimulation with Volatile Aroma Compounds of Basil ( Ocimum basilicum L.) Essential Oil and Linalool Ameliorates White Fat Accumulation and Dyslipidemia in Chronically Stressed Rats |
| Linoleic Acid | 📋 | ✍ | ⛔ | | 36676979 | Effect of Linoleic Acid on Cholesterol Levels in a High-Fat Diet-Induced Hypercholesterolemia Rat Model |
| Mango | 📋 | | ⛔ | | 34725636 | Therapeutic Role of Mango Peels in Management of Dyslipidemia and Oxidative Stress in Obese Females |
| Marjoram | 📋 | | ⛔ | | 32158345 | Anti-Hypolipidemic and Anti-Oxidative Effects of Hydroalcoholic Extract of Origanum majorana on the Hepatosteatosis Induced with High-Fat Diet in Rats |
| Mastic | 📋 | ✍ | ⛔ | | 35691258 | Efficacy of a standardized herbal product from Pistacia atlantica subsp. Kurdica in type 2 diabetic patients with hyperlipidemia: A triple-blind randomized clinical trial |
| Mucuna Pruriens | 📋 | ✍ | ⛔ | | 36458299 | Hypolipidemic and antioxidant effects of vegetal milk produced with Mucuna pruriens L. seed in rats fed a high-fat diet |
| MUFA | 📋 | | ⛔ | | 16969381 | Effects of hazelnut-enriched diet on plasma cholesterol and lipoprotein profiles in hypercholesterolemic adult men |
| N-Acetyl Cysteine | 📋 | ✍ | ⛔ | | 29796316 | Effect of N-Acetylcysteine on Dyslipidemia and Carbohydrate Metabolism in STZ-Induced Diabetic Rats |
| Neohesperidin | 📋 | | | | 28554169 | Neohesperidin Exerts Lipid-Regulating Effects in vitro and in vivo via Fibroblast Growth Factor 21 and AMP-Activated Protein Kinase/Sirtuin Type 1/Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1α Signaling Axis |
| Nicotinamide Riboside | 📋 | ✍ | ⛔ | | 25974041 | Nicotinamide Riboside Ameliorates Hepatic Metaflammation by Modulating NLRP3 Inflammasome in a Rodent Model of Type 2 Diabetes |
| NMN | 📋 | ✍ | ⛔ | | 36740954 | Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study |
| Noni | 📋 | | ⛔ | | 35175775 | Glycolipid Metabolism and Metagenomic Analysis of the Therapeutic Effect of a Phenolics-Rich Extract from Noni Fruit on Type 2 Diabetic Mice |
| Nutmeg | 📋 | ✍ | ⛔ | | 26199582 | African Nutmeg (Monodora Myristica) Lowers Cholesterol and Modulates Lipid Peroxidation in Experimentally Induced Hypercholesterolemic Male Wistar Rats |
| Okra | 📋 | | ⛔ | | 37507536 | Clinical efficacy and safety of okra (Abelmoschus esculentus (L.) Moench) in type 2 diabetic patients: a randomized, double-blind, placebo-controlled, clinical trial |
| Olive | 📋 | ✍ | ⛔ | | 38089061 | The antihyperlipidemic effect of a combined supplement of standardized dry extracts of amla ( Emblica officinalis), walnut ( Juglans regia), olive ( Olea europaea) and red yeast rice ( Monascus purpureus) powder: Reduction in circulatory low-density lipoprotein-cholesterol (LDL-C) and remnant cholesterol (RC) levels in patients with hypercholesterolemia |
| Orange Essential Oil | 📋 | ✍ | ⛔ | | 32760938 | Dietary citrus peel essential oil ameliorates hypercholesterolemia and hepatic steatosis by modulating lipid and cholesterol homeostasis |
| Parthenolide | 📋 | | | | 36234807 | First Discovery of Cholesterol-Lowering Activity of Parthenolide as NPC1L1 Inhibitor |
| Pear | 📋 | | ⛔ | | 12952433 | Apple and pear peel and pulp and their influence on plasma lipids and antioxidant potentials in rats fed cholesterol-containing diets |
| Pecan | 📋 | | ⛔ | | 36822079 | Pecan-enriched diet improves cholesterol profiles and enhances postprandial microvascular reactivity in older adults |
| Pectin | 📋 | ✍ | ⛔ | | 33897940 | Dietary Fiber: An Opportunity for a Global Control of Hyperlipidemia |
| Peony | 📋 | | ⛔ | | 35107625 | Peony seed oil decreases plasma cholesterol and favorably modulates gut microbiota in hypercholesterolemic hamsters |
| Perilla | 📋 | ✍ | | | 38053825 | Purple perilla frutescens extracts containing α-asarone inhibit inflammatory atheroma formation and promote hepatic HDL cholesterol uptake in dyslipidemic apoE-deficient mice |
| Polydatin | 📋 | ✍ | | | 38323270 | Polydatin ameliorates low-density lipoprotein cholesterol and lipid metabolism by downregulating proprotein convertase subtilisin/kexin type 9 (PCSK9) in triple-negative breast cancer with hyperlipidemia |
| Polyphenols | 📋 | | | | 24368433 | Diets naturally rich in polyphenols improve fasting and postprandial dyslipidemia and reduce oxidative stress: a randomized controlled trial |
| Prickly Pear | 📋 | | ⛔ | | 29564091 | The effect of Opuntia ficus-indica juice supplementation on oxidative stress, cardiovascular parameters, and biochemical markers following yo-yo Intermittent recovery test |
| Protein | 📋 | ✍ | ⛔ | | 37876152 | High Plant Protein Diet Ameliorated Hepatic Lipid Accumulation Through the Modulation of Gut Microbiota |
| Quercitrin | 📋 | | | | 33076582 | Quercitrin Ameliorates Hyperlipidemia and Hepatic Steatosis in Ovariectomized Mice |
| Quinoa | 📋 | | ⛔ | | 37476690 | Glucolipid metabolism improvement in impaired glucose tolerance subjects consuming a Quinoa-based diet: a randomized parallel clinical trial |
| Rapamycin | 📋 | ✍ | | | 31215250 | 4-Phenylbutyric acid and rapamycin improved diabetic status in high fat diet/streptozotocin-induced type 2 diabetes through activation of autophagy |
| Red Clover | 📋 | ✍ | ⛔ | | 22084061 | Red clover extract ameliorates dyslipidemia in streptozotocin-induced diabetic C57BL/6 mice by activating hepatic PPARα |
| Red Sage | 📋 | ✍ | ⛔ | | 28840970 | Evaluating Efficacy and Safety of Combination Medication of Atorvastatin and a Herbal Formula Containing Salvia miltiorrhiza and Pueraria lobata on Hyperlipidemia |
| Rhubarb | 📋 | | ⛔ | | 37808167 | Mechanism of rhubarb in the treatment of hyperlipidemia: A recent review |
| Rosehip | 📋 | ✍ | ⛔ | | 38283449 | Effects of Daily Intake of Rosehip Extract on Low-Density Lipoprotein Cholesterol and Blood Glucose Levels: A Systematic Review |
| Rosehip Seed Oil | 📋 | | ⛔ | | 32992796 | Sea Buckthorn and Rosehip Oils with Chokeberry Extract to Prevent Hypercholesterolemia in Mice Caused by a High-Fat Diet In Vivo |
| Rosmarinic Acid | 📋 | ✍ | | | 34680102 | Rosmarinic Acid Exhibits a Lipid-Lowering Effect by Modulating the Expression of Reverse Cholesterol Transporters and Lipid Metabolism in High-Fat Diet-Fed Mice |
| Rye | 📋 | | ⛔ | | 37898434 | Effects of Wholegrain Compared to Refined Grain Intake on Cardiometabolic Risk Markers, Gut Microbiota and Gastrointestinal Symptoms in Children: A Randomized Crossover Trial |
| Sage Essential Oil | 📋 | | ⛔ | | 32010989 | The protective effects of Salvia officinalis essential oil compared to simvastatin against hyperlipidemia, liver, and kidney injuries in mice submitted to a high-fat diet |
| Salt | 📋 | | ⛔ | | 33524391 | Dietary sodium restriction alters muscle lipidomics that relates to insulin resistance in mice |
| Sardine | 📋 | | ⛔ | | 36860672 | Cardiovascular and lipid-lowering effects of a marine lipoprotein extract in a high-fat diet-induced obesity mouse model |
| Saw Palmetto | 📋 | ✍ | ⛔ | | 34161166 | Standardized Saw Palmetto Extract Directly and Indirectly Affects Testosterone Biosynthesis and Spermatogenesis |
| Scutellarin | 📋 | | | | 29172017 | Scutellarin Prevents Nonalcoholic Fatty Liver Disease (NAFLD) and Hyperlipidemia via PI3K/AKT-Dependent Activation of Nuclear Factor (Erythroid-Derived 2)-Like 2 (Nrf2) in Rats |
| Sesamolin | 📋 | | | | 35396857 | Comparative effects of sesame lignans (sesamin, sesamolin, and sesamol) on oxidative stress and lipid metabolism in steatosis HepG2 cells |
| Shallot | 📋 | | ⛔ | | 36274534 | The effect of Allium hirtifolium bulb on serum lipid profile in adult patients with hyperlipidemia: A randomized double-blind placebo-controlled clinical trial |
| Shea | 📋 | | ⛔ | | 33364595 | Hypoglycemic, antidyslipidemic and antioxydant effects of Vitellaria paradoxa barks extract on high-fat diet and streptozotocin-induced type 2 diabetes rats |
| Soybean Oil | 📋 | | ⛔ | | 22205583 | Effect of soybean oil on atherogenic metabolic risks associated with estrogen deficiency in ovariectomized rats: dietary soybean oil modulate atherogenic risks in overiectomized rats |
| Stigmasterol | 📋 | | | | 31759199 | Stigmasterol stimulates transintestinal cholesterol excretion independent of liver X receptor activation in the small intestine |
| Sunflower | 📋 | | ⛔ | | 34194097 | Lipid profile of hyperlipidemic males after supplementation of multigrain bread containing sunflower ( Helianthus annuus) seed flour |
| Sunflower Oil | 📋 | ✍ | ⛔ | | 37627620 | Ozonated Sunflower Oil Exerted Potent Anti-Inflammatory Activities with Enhanced Wound Healing and Tissue Regeneration Abilities against Acute Toxicity of Carboxymethyllysine in Zebrafish with Improved Blood Lipid Profile |
| Tea Polyphenols | 📋 | | | | 36444016 | Tea polyphenol and epigallocatechin gallate ameliorate hyperlipidemia via regulating liver metabolism and remodeling gut microbiota |
| Theobromine | 📋 | ✍ | ⛔ | | 23595874 | Effect of cocoa and theobromine consumption on serum HDL-cholesterol concentrations: a randomized controlled trial |
| Thyme | 📋 | ✍ | ⛔ | | 26011257 | Complementary phenol-enriched olive oil improves HDL characteristics in hypercholesterolemic subjects. A randomized, double-blind, crossover, controlled trial. The VOHF study |
| Tongkat Ali | 📋 | ✍ | ⛔ | | 32708678 | The Powdered Root of Eurycoma longifolia Jack Improves Beta-Cell Number and Pancreatic Islet Performance through PDX1 Induction and Shows Antihyperglycemic Activity in db/db Mice |
| Trans-Resveratrol | 📋 | | | | 34999386 | Comprehensive assessment of the effectiveness of l-carnitine and transresveratrol in rats with diet-induced obesity |
| Tribulus Terrestris | 📋 | ✍ | ⛔ | | 27840471 | Efficacy of Tribulus Terrestris Extract on the Serum Glucose and Lipids of Women with Diabetes Mellitus |
| TUDCA | 📋 | ✍ | ⛔ | | 37687178 | Metabolomics and Lipidomics Study Unveils the Impact of Tauroursodeoxycholic Acid on Hyperlipidemic Mice |
| Ursolic Acid | 📋 | ✍ | ⛔ | | 35671633 | Ursolic acid inhibits the cholesterol biosynthesis and alleviates high fat diet-induced hypercholesterolemia via irreversible inhibition of HMGCS1 in vivo |
| Vitamin B1 | 📋 | ✍ | ⛔ | | 34094512 | Association between levels of thiamine intake, diabetes, cardiovascular diseases and depression in Korea: a national cross-sectional study |
| Vitamin B12 | 📋 | ✍ | ⛔ | | 32529103 | A double-blind, placebo-controlled clinical trial to assess the effects of a combined nutraceutical on endothelial function in patients with mild-to-moderate hypercholesterolaemia |
| Vitamin B8 | 📋 | ✍ | ⛔ | | 38137721 | Combined Inositols, α-Lactalbumin, Gymnema Sylvestre and Zinc Improve the Lipid Metabolic Profile of Patients with Type 2 Diabetes Mellitus: A Randomized Clinical Trial |
| Vitamin K | 📋 | ✍ | ⛔ | | 33454929 | A critical review of the effects of vitamin K on glucose and lipid homeostasis: its potential role in the prevention and management of type 2 diabetes |
| Wasabi | 📋 | | ⛔ | | 36360048 | Wasabi ( Eutrema japonicum) Reduces Obesity and Blood Pressure in Diet-Induced Metabolic Syndrome in Rats |
| Wheat | 📋 | | ⛔ | | 35408659 | The Hypolipidemic and Antioxidant Activity of Wheat Germ and Wheat Germ Protein in High-Fat Diet-Induced Rats |
| Yam | 📋 | | | | 38613011 | A Comparative Analysis between Whole Chinese Yam and Peeled Chinese Yam: Their Hypolipidemic Effects via Modulation of Gut Microbiome in High-Fat Diet-Fed Mice |
| Yerba Mate | 📋 | ✍ | ⛔ | | 38327997 | Ilex paraguariensis A.St.-Hil. improves lipid metabolism in high-fat diet-fed obese rats and suppresses intracellular lipid accumulation in 3T3-L1 adipocytes via the AMPK-dependent and insulin signaling pathways |
| Yogurt | 📋 | | ⛔ | | 36484237 | The ability of yoghurt supplemented with dietary fibers or brans extracted from wheat or rice to reduce serum lipids and enhance liver function in male hypercholesterolemic rats |
| Zingerone | 📋 | | | | 25558849 | Antihyperlipidaemic, antihypertrophic, and reducing effects of zingerone on experimentally induced myocardial infarcted rats |
